Sascha Dublin, MD, PhD, is a general internist and epidemiologist who studies the health effects of prescription medications and other interventions using real-world health care data. Through her work, she aims to provide better information about the risks and benefits of different treatments so patients and doctors can make well-informed decisions.
Much of Dr. Dublin’s research focuses on the outcomes of medication use or other interventions during pregnancy. These studies take advantage of the rich clinical data available through electronic health records (EHRs). Some of her current work in this area includes:
Dr. Dublin recently led an impactful study with Kaiser Permanente Washington Health Research Institute colleagues exploring different methods to screen for diabetes in pregnancy. This work examined how outcomes changed for mothers and babies after Kaiser Permanente Washington made a big shift in their approach to gestational diabetes screening. This project found that a new, more intensive approach to screening did not improve health outcomes, and may have even worsened some. As a result, Kaiser Permanente Washington changed back to the previous, more widely used screening approach.
Beyond pregnancy, Dr. Dublin’s work includes studies of medication use and dementia risk in older adults. For example, her team found that heavy use of some commonly used medications including antihistamines increases dementia risk. They also found that one widely used medication class, proton pump inhibitors, does not increase the risk of dementia—in contrast to some earlier reports—or fractures.
Dr. Dublin has a strong interest in epidemiologic methods, particularly finding ways to better measure important variables. She has led methods workgroups for the FDA’s Sentinel Initiative and has experience using natural language processing and collecting data from patients through mobile phone apps. Dr. Dublin also has interest and expertise in improving the rigor and validity of observational studies by improving how they account for patients’ other illnesses and overall health status.
Dr. Dublin previously held a Paul B. Beeson Career Development Award (K23) from the National Institute on Aging. She sees patients one day a week in primary care at Kaiser Permanente Washington.
Dublin S, Wartko P, Mangione-Smith R. Studying medication safety in pregnancy: a call for new approaches, resources, and collaborations. Pediatrics. 2020 Jul;146(1):e20201540. doi: 10.1542/peds.2020-1540. Epub 2020 Jun 8. PubMed
Harding BN, Floyd JS, Scherrer JF, Salas J, Morley JE, Farr SA, Dublin S. Methods to identify dementia in the electronic health record: comparing cognitive test scores with dementia algorithms. Healthc (Amst). 2020;8(2):100430. doi: 10.1016/j.hjdsi.2020.100430. Epub 2020 May 22. PubMed
Salas J, Morley JE, Scherrer JF, Floyd JS, Farr SA, Zubatsky M, Barthold D, Dublin S. Risk of incident dementia following metformin initiation compared with noninitiation or delay of antidiabetic medication therapy. Pharmacoepidemiol Drug Saf. 2020 May 3. doi: 10.1002/pds.5014. [Epub ahead of print]. PubMed
Chen L, Shortreed SM, Easterling T, Cheetham TC, Reynolds K, Avalos LA, Kamineni A, Holt V, Neugebauer R, Akosile M, Nance N, Bider-Canfield Z, Walker RL, Badon SE, Dublin S. Identifying hypertension in pregnancy using electronic medical records: the importance of blood pressure values. Pregnancy Hypertens. 2020 Jan;19:112-118. doi: 10.1016/j.preghy.2020.01.001. Epub 2020 Jan 3. PubMed
In a new study, a tool to help discover undiagnosed dementia performed well in 2 separate health systems.
A study led by Dr. Sascha Dublin finds similar outcomes for 3 hypertension medications, filling an evidence gap.
Dr. Sascha Dublin explains why sometimes not taking medications may be a safer and healthier choice.
Clinical Lab Manager, Nov. 1, 2020